Hepatocyte growth factor

<StructureSection load='1shy' size='350' side='right' caption='Structure of human HGF β chain complex with HGF receptor Sema and ψ domains (PDB entry 1shy)' scene=>

Hepatocyte growth factor (HGF) regulates cell growth, motility and morphogenesis. HGF binds to proto-oncogene c-Met receptor and activates a tyrosine kinase signaling cascade. HGF precursor is cleaved by serine protease to α and β (residues 495-728) chains which form a disulfide bond to produce the active heterodimer. HGF NK1 variant is comprised of residues 28-210 containing the N-terminus and the first kringle domain of HGF. HGF NK2 variant is comprised of residues 28-289 containing the N-terminus and the first 2 kringle domains of HGF.

3D structures of hepatocyte growth factor3D structures of hepatocyte growth factor

Updated on 12-May-2013

HGF N terminalHGF N terminal

2hgf – hHGF N terminal – human - NMR
3hms, 3hmt – hHGF N terminal
3hmr – mHGF N terminal – mouse

HGF NK1 variantHGF NK1 variant

1bht, 1nk1, 1gp9, 2qj2, 2qj4 – hHGF NK1
1gmn, 1gmo, 3mkp – hHGF NK1 (mutant) + heparin

HGF NK2 variantHGF NK2 variant

3hn4 – hHGF NK2
3sp8 – hHGF NK2 (mutant) + heparin
4iua – mHGF NK2 (mutant)

HGF β chainHGF β chain

1si5 – hHGF β chain (mutant)
1shy – hHGF β chain (mutant) + HGF receptor Sema and ψ domains