Growth factor receptor-bound protein

File:1tze.png

Crystal structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) 1tze

Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRB2 links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. GRB7 interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway. GRB10 interacts with insulin receptor and insulin-like growth factor receptors. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. For additional details on GRB10 see Grb10 SH2 Domain.

3D structures of Grb3D structures of Grb

Updated on 09-May-2013

GRB2GRB2

1gri, 2h46 – hGRB2 – human

GRB2 C terminal SH3 domain

1gfc, 1gfd – hGRB2 C terminal SH3 domain - NMR
2vvk, 2vwf, 2w0z – hGRB2 C terminal SH3 domain
1io6 – hGRB2 C terminal SH3 domain + ligand peptide - NMR
1gcq – hGRB2 C terminal SH3 domain + VAV proto-oncogene SH3 domain

GRB2 N terminal SH3 domain

1gbr, 1gbq, 2gbq, 3gbq, 4gbq – mGRB2 N terminal SH3 domain + Sos-A peptide – mouse - NMR
1aze – mGRB2 N terminal SH3 domain + Sos-A peptide - NMR

GRB2 SH2 domain

1jyu – hGRB2 SH2 domain
1ghu – hGRB2 SH2 domain (mutant) - NMR
1fhs – hGRB2 SH2 domain - NMR
1x0n – hGRB2 SH2 domain + inhibitor - NMR
2huw – hGRB2 SH2 domain + cyclopropane derivative
1cj1 – hGRB2 SH2 domain + phosphor-Tyr derivative
2aoa, 2aob – hGRB2 SH2 domain + peptide mimetic
1tze, 1bmb, 1bm2, 1zfp, 1fyr, 1jyq, 1jyr, 2h5k, 3c7i, 3imd, 3imj, 3in7, 3in8, 3kfj, 3n8m, 3n7y, 3n84, 3mxc, 3mxy, 3ov1, 3ove, 3s8l, 3s8n, 3s8o, 1zfp – hGRB2 SH2 domain + phosphor-Tyr peptide
1qg1 – hGRB2 SH2 domain + phosphor-Tyr peptide - NMR

GRB4GRB4

4e6r – hGRB4 C terminal SH3 domain

GRB7GRB7

2qms – hGRB7 SH2 domain
1mw4, 2l4k – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR
3pqz – hGRB7 SH2 domain + cyclic peptide
1wgr – hGRB7 RA domain - NMR

GRB10GRB10

1nrv – hGRB10 SH2 domain
3m7f – hGRB10 SH2 domain + NEDD4 C2 domain
3hk0 – hGRB10 RA and PH domains

GRB14GRB14

2aug – hGRB14 SH2 domain
2auh – hGRB14 BPS domain + insulin receptor kinase domain

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman