4amv
E.COLI GLUCOSAMINE-6P SYNTHASE IN COMPLEX WITH FRUCTOSE-6PE.COLI GLUCOSAMINE-6P SYNTHASE IN COMPLEX WITH FRUCTOSE-6P
FunctionFunction
[GLMS_ECOLI] Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
About this StructureAbout this Structure
4amv is a 3 chain structure with sequence from Escherichia coli. This structure supersedes the now removed PDB entry 2bpl. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Mouilleron S, Badet-Denisot MA, Golinelli-Pimpaneau B. Glutamine binding opens the ammonia channel and activates glucosamine-6P synthase. J Biol Chem. 2006 Feb 17;281(7):4404-12. Epub 2005 Dec 9. PMID:16339762 doi:10.1074/jbc.M511689200
- ↑ Mouilleron S, Golinelli-Pimpaneau B. Domain motions of glucosamine-6P synthase: comparison of the anisotropic displacements in the crystals and the catalytic hinge-bending rotation. Protein Sci. 2007 Mar;16(3):485-93. PMID:17322533 doi:16/3/485
- ↑ Mouilleron S, Badet-Denisot MA, Golinelli-Pimpaneau B. Ordering of C-terminal loop and glutaminase domains of glucosamine-6-phosphate synthase promotes sugar ring opening and formation of the ammonia channel. J Mol Biol. 2008 Apr 4;377(4):1174-85. Epub 2008 Feb 4. PMID:18295797 doi:10.1016/j.jmb.2008.01.077