Thymidylate kinase
Thymidylate kinase (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. The TMK inhibitor azido-dTMP (AZTP) is an HIV AZT prodrug metabolite.
3D Structures of thymidylate kinase3D Structures of thymidylate kinase
Updated on 24-April-2013
2cck, 4f4i – SaTMK – Staphylococcus aureus
2pbr – TMK – Aquifex aeolicus
2plr – TMK – Sulfolobus tokodaii
3ld9 – TMK – Ehrlichia chafeensis
3v9p – TMK – Burkholderia thailandensis
3uwk, 3uwo – PaTMK – Pseudomonas aeruginosa
TMK complex with HIV prodrug AZT derivativeTMK complex with HIV prodrug AZT derivative
2tmk – yTMK + AZTP
4eaq – SaTMK + AZTP
4gmd – PaTMK + AZTP
4tmk, 5tmp – TMK + AZTP – Escherichia coli
1w2h – MtTMK + AZTP - Mycobacterium tuberculosis
1e98, 1e99, 1e9d – hTMK (mutant) + AZTP + ADP
TMK complex with nucleotidesTMK complex with nucleotides
2v54 – VvTMK + TDP – Vaccinia virus
2w0s – VvTMK + brivudin-MP
1tmk – yTMK + dTMP - yeast
4e5u – PaTMK + dTMP
2ccg, 2ccj, 4dwj – SaTMK + dTMP
1g3u, 1gsi, 1n5i, 1n5k – MtTMK + dTMP
1w2g – MtTMK + thymidine
1gtv – MtTMK + TDP
1n5j – MtTMK + TDP + TTP
1n5l – MtTMK + TDP + dTMP
1mrs – MtTMK + UMP derivative
3uxm, 4esh – PaTMK + deoxy thymidine derivative
3hjn – TMK + ADP + TDP – Thermotoga maritima
1e2d, 1e2e, 1e2f, 1e9e, 1e9f – hTMK (mutant) + ADP + dTMP - human
1e9f – hTMK (mutant) + ADP + dTMP - human
4edh – PaTMK + ADP + dTMP
3lv8 – VcTMK + ADP + dTMP + TDP – Vibrio cholerae
3n2i – VcTMK + thymidine + thymidine deoxy-thymidine
1e9b – hTMK (mutant) + azido-TMP + APPNP
1e9c – hTMK (mutant) + dTMP + APPNP
1nmx – hTMK (mutant) + F-TMP + ADP
1nmy, 1nn0, 1nnz, 1nn1, 1nn3, 1nn5, 1nmz – hTMK (mutant) + dTMP derivative + APPNP
2xx3 – hTMK + dTMP derivative + ADP
Other TMK binary complexesOther TMK binary complexes
4gfd, 4hlc, 4hld, 4hej, 4hdc – SaTMK + antibacterial drug
4gsy – SaTMK + inhibitor
TMK complex with bisubstrate inhibitorTMK complex with bisubstrate inhibitor
1mrn – MtTMK + TP5A
3tmk – yTMK + TP5A
1e9a – hTMK (mutant) + azido-TP5A + ADP