Template:STRUCTURE 3mul

Crystal structure of Brd4 bromodomain 1 with butyrylated histone H3-K(buty)14Crystal structure of Brd4 bromodomain 1 with butyrylated histone H3-K(buty)14

FunctionFunction

[BRD4_MOUSE] Plays a role in a process governing chromosomal dynamics during mitosis.[1]

About this StructureAbout this Structure

3mul is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. Vollmuth F, Geyer M. Interaction of propionylated and butyrylated histone H3 lysine marks with Brd4 bromodomains. Angew Chem Int Ed Engl. 2010 Sep 10;49(38):6768-72. PMID:20715035 doi:10.1002/anie.201002724
  1. Dey A, Ellenberg J, Farina A, Coleman AE, Maruyama T, Sciortino S, Lippincott-Schwartz J, Ozato K. A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. Mol Cell Biol. 2000 Sep;20(17):6537-49. PMID:10938129

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