3mvi

Crystal structure of holo mADA at 1.6 A resolutionCrystal structure of holo mADA at 1.6 A resolution

Template:ABSTRACT PUBMED 20815357

FunctionFunction

[ADA_MOUSE] Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity).

About this StructureAbout this Structure

3mvi is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}^{[xtra 2]}

↑ Niu W, Shu Q, Chen Z, Mathews S, Di Cera E, Frieden C. The Role of Zn(2+) on the Structure and Stability of Murine Adenosine Deaminase (dagger). J Phys Chem B. 2010 Sep 3. PMID:20815357 doi:10.1021/jp106041v
↑ Wang Z, Quiocho FA. Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity. Biochemistry. 1998 Jun 9;37(23):8314-24. PMID:9622483 doi:10.1021/bi980324o

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OCA

[1] Niu W, Shu Q, Chen Z, Mathews S, Di Cera E, Frieden C. The Role of Zn(2+) on the Structure and Stability of Murine Adenosine Deaminase (dagger). J Phys Chem B. 2010 Sep 3. PMID:20815357 doi:10.1021/jp106041v

[2] Wang Z, Quiocho FA. Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity. Biochemistry. 1998 Jun 9;37(23):8314-24. PMID:9622483 doi:10.1021/bi980324o

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