Protein phosphatase

File:3k7v.png

Crystal structure of human PP2A catalytic and regulatory subunits complex with tumor-inducing toxin binding protein 3k7v

Protein phosphatases (PP) regular protein phosphorylation and thus are key in intracellular signal transduction processes. PP1 is a serine/threonine phosphatase. PP2A targets proteins in the oncogenic signaling pathways. PP2C are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways. PP4 regulates a variety of cellular functions. PP5 is activated by lipids and is involved in signal transduction. For PP2A see also HEAT Repeat.

3D Structures of protein phosphatase3D Structures of protein phosphatase

Updated on 07-April-2013

PP1APP1A

3fxj, 3fxk, 3fxl, 3fxm, 3fxo – hPP1A + Mn – human
4da1 – hPP1K + Mn
1jk7, 1u32, 2bcd, 2bdx, 3e7a, 3e7b – hPP1 catalytic subunit + tumor-inducing toxin
1fjm – PP1 + tumor-inducing toxin - rabbit
3egg – hPP1 catalytic subunit + spinophilin
3hvq – hPP1 catalytic subunit + neuroabin
3n5u – hPP1A catalytic subunit + retinoblastoma-associated protein
3v4y – hPP1A catalytic subunit + PP1 nuclear inhibitor
4g9j – hPP1A catalytic subunit + peptide
3egh – hPP1 catalytic subunit + spinophilin + toxin
1it6 – hPP1 catalytic subunit + calyculin
1s70 – hPP1 catalytic subunit (mutant) + smooth muscle myosin phosphatase
2o8a, 2o8g – PP1C catalytic subunit + inhibitor - rat
2rlt – PP1 regulatory subunit – pig - NMR

PP2APP2A

1b3u, 2ixm, 2jak, 2g62 – hPP2A regulatory subunit
2pkg – hPP2A regulatory subunit + small T antigen
2pf4 – PP2A regulatory subunit + small T antigen - mouse
2ie3, 2ie4, 2npp, 2nyl, 2nym, 2iae, 3dw8, 3k7v, 3k7w – hPP2A catalytic + regulatory subunit + tumor-inducing toxin
3fga – hPP2C catalytic + regulatory subunit + tumor-inducing toxin + Sgo
3c5w – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase
3c5w, 3p71 – hPP2A catalytic subunit + leucine carboxyl methyltransferase

PP2CPP2C

1a6q – hPP2C
2iq1 – hPP2C κ
2p8e – hPP2C β
2cm1 – PP2C + Mn – Micobacterium tuberculosis
3d8k – PP2C – Toxoplasma gondii
3jrq, 3kdj, 3nmn – AtPP2C + Pyl1 – Arabidopsis thaliana
3nmt, 3kb3, 3nmv, 3ujl – AtPP2C + Pyl2
4ds8 – AtPP2C + Pyl3 + Mn
3rt0 – AtPP2C (mutant) + Pyl10
3qn1, 3zvu – AtPP2C + Pyr1
3ujg – AtPP2C + SNRK2
3ujk – AtPP2C

PP5PP5

1s95 – hPP5 catalytic domain
2g62 – hPP5
2bug – hPP5 tetratricopeptide domain + Hsp90 peptide
3h60 – hPP5 catalytic domain + Mn
3h61, 3h62, 3h63, 3h64 – hPP5 catalytic domain + Mn + inhibitor
3h66 – hPP5 catalytic domain + Zn
3h67, 3h68, 3h69 – hPP5 catalytic domain + Zn + inhibitor