3ld6

Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazoleCrystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole

Template:ABSTRACT PUBMED 20149798

FunctionFunction

[CP51A_HUMAN] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

About this StructureAbout this Structure

3ld6 is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3i3k. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Strushkevich N, Usanov SA, Park HW. Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol. 2010 Apr 9;397(4):1067-78. Epub 2010 Feb 10. PMID:20149798 doi:10.1016/j.jmb.2010.01.075

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Strushkevich N, Usanov SA, Park HW. Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol. 2010 Apr 9;397(4):1067-78. Epub 2010 Feb 10. PMID:20149798 doi:10.1016/j.jmb.2010.01.075

[xtra 1]