4ie2
Crystal structure of human Arginase-2 complexed with inhibitor 1hCrystal structure of human Arginase-2 complexed with inhibitor 1h
FunctionFunction
[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
About this StructureAbout this Structure
4ie2 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.