1o7d
THE STRUCTURE OF THE BOVINE LYSOSOMAL A-MANNOSIDASE SUGGESTS A NOVEL MECHANISM FOR LOW PH ACTIVATIONTHE STRUCTURE OF THE BOVINE LYSOSOMAL A-MANNOSIDASE SUGGESTS A NOVEL MECHANISM FOR LOW PH ACTIVATION
Template:ABSTRACT PUBMED 12634058
DiseaseDisease
[MA2B1_BOVIN] Note=Defects in MAN2B1 are the cause of lysosomal alpha-mannosidosis (AM). AM is a lysosomal storage disease characterized by accumulation of unbranched oligosaccharide chains. The disease manifests itself by head tremor, aggressive tendency, ataxia, failure to thrive, and early death.
FunctionFunction
[MA2B1_BOVIN] Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.
About this StructureAbout this Structure
1o7d is a 5 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.