2hev
Crystal structure of the complex between OX40L and OX40Crystal structure of the complex between OX40L and OX40
Template:ABSTRACT PUBMED 16905106
DiseaseDisease
[TNFL4_HUMAN] Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.[1]
FunctionFunction
[TNFL4_HUMAN] Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. [TNR4_HUMAN] Receptor for TNFSF4/OX40L/GP34.
About this StructureAbout this Structure
2hev is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Compaan DM, Hymowitz SG. The crystal structure of the costimulatory OX40-OX40L complex. Structure. 2006 Aug;14(8):1321-30. PMID:16905106 doi:10.1016/j.str.2006.06.015
- ↑ Cunninghame Graham DS, Graham RR, Manku H, Wong AK, Whittaker JC, Gaffney PM, Moser KL, Rioux JD, Altshuler D, Behrens TW, Vyse TJ. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet. 2008 Jan;40(1):83-9. Epub 2007 Dec 2. PMID:18059267 doi:ng.2007.47