1pue

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Template:STRUCTURE 1pue

PU.1 ETS DOMAIN-DNA COMPLEXPU.1 ETS DOMAIN-DNA COMPLEX

Template:ABSTRACT PUBMED 8602247

DiseaseDisease

[SPI1_MOUSE] Note=Involved in murine acute Friend erythroleukemia. It is a target region for SFFV proviral insertion.

FunctionFunction

[SPI1_MOUSE] Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.[1]

About this StructureAbout this Structure

1pue is a 6 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1][xtra 2][xtra 3]

  1. ↑ Kodandapani R, Pio F, Ni CZ, Piccialli G, Klemsz M, McKercher S, Maki RA, Ely KR. A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex. Nature. 1996 Apr 4;380(6573):456-60. PMID:8602247 doi:http://dx.doi.org/10.1038/380456a0
  2. ↑ Cokol M, Nair R, Rost B. Finding nuclear localization signals. EMBO Rep. 2000 Nov;1(5):411-5. PMID:11258480 doi:10.1093/embo-reports/kvd092
  3. ↑ Hicks JM, Hsu VL. The extended left-handed helix: a simple nucleic acid-binding motif. Proteins. 2004 May 1;55(2):330-8. PMID:15048824 doi:10.1002/prot.10630
  1. ↑ Hallier M, Tavitian A, Moreau-Gachelin F. The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. J Biol Chem. 1996 May 10;271(19):11177-81. PMID:8626664

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