1hti

spinqualitylabelsall models PDB ID 1hti Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1hti, resolution 2.80Å ()
Ligands:
Activity:	Triose-phosphate isomerase, with EC number 5.3.1.1
Structural annotation: Resources: CATH : 1Htia00, 1Htib00 InterPro : Ipr000652, Ipr013785 Pfam : PF00121 SCOP : d1htia_, d1htib_ UniProt : P60174
Functional annotation: Biological process: glycolysis gluconeogenesis pentose-phosphate shunt fatty acid biosynthetic process lipid biosynthetic process metabolic process Molecular function: isomerase activity triose-phosphate isomerase activity catalytic activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

DiseaseDisease

[TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.

About this StructureAbout this Structure

1hti is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See AlsoSee Also

• Triose Phosphate Isomerase