3cem
Human glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE9423Human glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE9423
Template:ABSTRACT PUBMED 18373353
DiseaseDisease
[PYGL_HUMAN] Defects in PYGL are the cause of glycogen storage disease type 6 (GSD6) [MIM:232700]. A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected.[1]
FunctionFunction
[PYGL_HUMAN] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
About this StructureAbout this Structure
3cem is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Anderka O, Loenze P, Klabunde T, Dreyer MK, Defossa E, Wendt KU, Schmoll D. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry. 2008 Apr 22;47(16):4683-91. Epub 2008 Mar 29. PMID:18373353 doi:10.1021/bi702397d
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OCACategories:
- Homo sapiens
- Phosphorylase
- Anderka, O.
- Defossa, E.
- Dreyer, M K.
- Klabunde, T.
- Loenze, P.
- Schmoll, D.
- Wendt, K U.
- Allosteric enzyme
- Allosteric inhibitor
- Carbohydrate metabolism
- Disease mutation
- Glycogen metabolism
- Glycogen storage disease
- Glycosyltransferase
- Nucleotide-binding
- Phosphoprotein
- Protein ligand complex
- Pyridoxal phosphate
- Tense state
- Transferase