1obv
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Y94F FLAVODOXIN FROM ANABAENA
OverviewOverview
Molecular recognition begins when two molecules approach and establish, interactions of certain strength. The mechanisms of molecular recognition, reactions between biological molecules are not well known, and few systems, have been analyzed in detail. We investigate here the reaction between an, apoprotein and its physiological cofactor (apoflavodoxin and flavin, mononucleotide) that binds reversibly to form a non-covalent complex, (flavodoxin) involved in electron transfer reactions. We have analyzed the, fast binding reactions between the FMN cofactor (and shorter analogs) and, wild type (and nine mutant apoflavodoxins where residues interacting with, FMN in the final complex have been replaced). The x-ray structures of two, such mutants are reported that show the mutations are well ... [(full description)]
About this StructureAbout this Structure
1OBV is a [Single protein] structure of sequence from [Anabaena sp.] with SO4 and FMN as [ligands]. Structure known Active Site: FMN. Full crystallographic information is available from [OCA].
ReferenceReference
How FMN binds to anabaena apoflavodoxin: a hydrophobic encounter at an open binding site., Lostao A, Daoudi F, Irun MP, Ramon A, Fernandez-Cabrera C, Romero A, Sancho J, J Biol Chem. 2003 Jun 27;278(26):24053-61. Epub 2003 Apr 7. PMID:12682068
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