1n0n
Catalytic and Structural Effects of Amino-Acid Substitution at His30 in Human Manganese Superoxide DismutaseCatalytic and Structural Effects of Amino-Acid Substitution at His30 in Human Manganese Superoxide Dismutase
DiseaseDisease
[SODM_HUMAN] Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
FunctionFunction
[SODM_HUMAN] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.[1]
About this StructureAbout this Structure
1n0n is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1lus. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ MacMillan-Crow LA, Thompson JA. Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. Arch Biochem Biophys. 1999 Jun 1;366(1):82-8. PMID:10334867 doi:S0003-9861(99)91202-X