Growth factor receptor-bound protein

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<StructureSection load='1tze' size='400' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry 1tze)' scene=>

Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRB2 links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. GRB7 interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway. GRB10 interacts with insulin receptor and insulin-like growth factor receptors.

3D structures of Grb3D structures of Grb

Updated on 18-March-2013

GRB2GRB2

1ghu – hGRB2 SH2 domain (mutant) – human
1fhs, 1jyu, 2aoa, 2h46 - hGRB2 SH2 domain
2vvk, 2vwf, 2w0z - hGRB2 SH3 domain
1tze, 1bmb, 1bm2, 1zfp, 1qg1, 1jyq, 1jyr, 2aob, 2h5k, 2huw, 3c7i, 3imd, 3imj, 3in7, 3in8, 3kfj, 3n8m, 3n7y, 3n84, 3mxc, 3mxy, 3ov1, 3ove, 3s8n, 3s8o - hGRB2 SH2 domain + phosphotyrosyl peptide
1x0n - hGRB2 SH2 domain + inhibitor - NMR
1cj1 - hGRB2 SH2 domain + phosphotyrosyl derivative
1gbq, 2gbq, 3gbq, 4gbq, 1aze - GRB2 SH3 domain + SOS-1 peptide – NMR
1io6, 1h3h - GRB2 SH3 domain + ligand peptide – NMR

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
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