Eukaryotic initiation factor

Eukaryotic initiation factors (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG. For details on EIF4 see Death Associated Protein 5.

3D structures of eukaryotic initiation factor3D structures of eukaryotic initiation factor

Updated on 07-March-2013

EIF1EIF1

2if1, 1d7q – hEIF1 – human – NMR
2ogh - yEIF1 – NMR

EIF2EIF2

1kl9 – hEIF2A
1q8x – hEIF2A - NMR
1si2, 1si3, 4ei3, 4f3t – hEIF2C PAZ domain + DNA
3luk - hEIF2C MID domain
3lud, 3lug, 3luh, 3luj, 3qx8, 3qx9 - hEIF2C MID domain + nucleotide
1q46 – yEIF2A – yeast
2a19, 2a1a – yEIF2A (mutant) + interferon-induced protein kinase
3ecs – hEIF2B

EIF3EIF3

2nlw - hEIF3B RNA recognition domain – NMR
3ns5, 3ns6 - yEIF3B RNA recognition domain
2krb - hEIF3B RNA recognition domain + hEIF3J peptide
2cq0 – hEIF3G RNA recognition domain – NMR
3zwl - yEIF3I + EIF3B C terminal
3bpj – hEIF3J
1rz4 – hEIF3K

EIF4EIF4

1fuk – yEIF4A C terminal
1fuu - yEIF4A mRNA helicase domain
2g9n, 3bor – hEIF4A DEAD domain
3ex7, 2xb2 – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA
2zu6, 3eiq – hEIF4A + programmed cell death protein
1wi8, 2j76 – hEIF4B RNA recognition domain - NMR
1ejh – mEIF4E + EIF4G peptide + GDP – mouse
1ej1, 1l8b - mEIF4E + nucleotide
2gpq, 3tf2 – hEIF4E
2wmc - EIF4E - pea
2idr – wEIF4E – wheat
2idv - wEIF4E (mutant) + GDP
1ipb, 1ipc - hEIF4E + nucleotide
4dt6, 4dum – hEIF4E + inhibitor
2w97 – hEIF4E + hEIF4G peptide
1wkw - hEIF4E + EIF4E-binding protein peptide + GDP
2v8w, 2v8x, 2v8y, 3u7x - hEIF4E + EIF4E-binding protein peptide
3am7 - hEIF4E + EIF4E-binding protein peptide + nucleotide
1ej4 - mEIF4E + EIF4E-binding protein peptide
3hxg, 3hxi - EIF4E + EIF4E-binding protein peptide + GDP – Schistosoma mansoni
3m93, 3m94 - EIF4E + EIF4E-binding protein peptide + nucleotide – Pig roundworm
1ap8 – yEIF4E + GDP – NMR
1rf8 - yEIF4E + yEIF4GI peptide + GDP
2vso, 2vsx - yEIF4E + yEIF4F
3l6a - hEIF4GII C terminal
1ug3 – hEIF4GI C terminal (mutant)
1hu3, 3d3m – hEIF4GII middle domain
2dng – hEIF4H RNA recognition domain – NMR

EIF5EIF5

1eif, 2eif – EIF5A – Methanocaldococcus janaschii
1x6o – EIF5A – Leishmania braziliensis
1xtd - EIF5A – Leishmania mexicana
3hks – EIF5A – Arabidopsis thaliana
3cpf - hEIF
2ful – yEIF5 C terminal
2iu1 - hEIF5 C terminal
2g2k – hEIF5 N terminal (mutant) – NMR
2e9h – hEIF5 – NMR
3cpf – hEIF5A
3er0 - yEIF5A

EIF6EIF6

1g62 – yEIF6
2x7n – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24