Cruzain (Cru) is the major cysteine protease present in Trypanosoma cruzi which is the parasite causing Chagas disease.

3D structures of cruzain

Updated on 14-May-2025

1aim, 2aim, 1me3, 1me4 – Cru catalytic domain + methylketone inhibitor – Trypanosoma cruzi

1f29, 1f2a, 1f2b, 1f2c, 1ewo, 3lxs - Cru catalytic domain + vinyl sulfone derived inhibitor
1ewl, 1ewm – Cru catalytic domain + methylbutane inhibitor


Structure of cruzain complex with methylketone inhibitor (PDB entry 1me3)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky