Aspartate-semialdehyde dehydrogenase
Aspartate-semialdehyde dehydrogenase (ASADH) is an enzyme which is part of the biosynthesis of amino acids. It catalyzes the conversion of L-aspartate 4-semialdehyde (ASA) + phosphate + NADP to L-4-aspartyl phosphate + NADPH + H+. The images at the left and at the right correspond to one representative ASADH, i.e. the crystal structure of Aspartate-semialdehyde dehydrogenase from Vibrio cholerae (1mc4).
3D Structures of Aspartate-semialdehyde dehydrogenase3D Structures of Aspartate-semialdehyde dehydrogenase
Update January 2013
2qz9, 1mc4 – VcASADH II – Vibrio cholerae
2yv3 – ASADH – Thermus thermiphilus
1t4d, 1t4b, 1brm - EcASADH β - Escherichia coli
1pu2, 1oza, 1pr3, 1ps8 - HiASADH (mutant) – Haemophilus influenzae
1nwc – HiASADH
1nwh – HiASADH reaction intermediate
2gyy – SpASADH – Streptococcus pneumonia
3uw3 - ASADH – Burkholderia thailandensis
ASADH binary complexASADH binary complex
2r00 - VcASADH II + ASA
3llg, 3vos – MtASADH + glycerol+ anion – Mycobacterium tuberculosis
3hsk – ASADH + NADP – Candida albicans
1ys4 - ASADH + NADP – Methanocaldococcus jannaschii
1nx6 - HiASADH reaction intermediate +Pi
1ta4 - HiASADH + As
1tb4 - HiASADH + IO4
1q2x - HiASADH (mutant) + ASA
2gz1 - SpASADH + NADP
2gz2 - SpASADH + ADP
3pyl - SpASADH + diaminopropionate
3q0e - VcASADH + cysteine sulfoxide
3q1l - SpASADH + cysteamine
3tz6 - MtASADH + cysteine
ASADH ternary complexASADH ternary complex
1pqu - HiASADH (mutant) + NADP + cacodylate + substrate analog
1pqp - HiASADH (mutant) + ASA + Pi
1gl3 - EcASADH β + NADP + substrate analog
1mb4 - VcASADH + NADP + substrate analog
3pzr - VcASADH + NADP + carbamoyl-cysteine
2gz3 - SpASADH + NADP + ASA
3pwk, 3pws - SpASADH + NADP + aminoadipate
3pyx - SpASADH + NADP + aminoterephthalate
3pzb - SpASADH + NADP + diaminopropionate
3q11 - SpASADH + NADP + inhibitor