1hkn
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A COMPLEX BETWEEN ACIDIC FIBROBLAST GROWTH FACTOR AND 5-AMINO-2-NAPHTHALENESULFONATE
OverviewOverview
Inhibition of angiogenesis-promoting factors such as fibroblast growth, factors is considered to be a potential procedure for inhibiting solid, tumor growth. Although several peptide-based inhibitors are currently, under study, the development of antiangiogenic compounds of small, molecular size is a pharmacological goal of considerable interest. We have, already shown that certain naphthalene sulfonates constitute minimal, functional substitutes of the antiangiogenic compounds of the suramin and, suradista family. Using those data as a lead, we have carried out a, rational search for new angiogenesis inhibitors that could provide new, pharmacological insights for the development of antiangiogenic treatments., The results of the study strongly underline the relevance of the, ... [(full description)]
About this StructureAbout this Structure
1HKN is a [Single protein] structure of sequence from [Homo sapiens] with N2M as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Leads for development of new naphthalenesulfonate derivatives with enhanced antiangiogenic activity: crystal structure of acidic fibroblast growth factor in complex with 5-amino-2-naphthalene sulfonate., Fernandez-Tornero C, Lozano RM, Redondo-Horcajo M, Gomez AM, Lopez JC, Quesada E, Uriel C, Valverde S, Cuevas P, Romero A, Gimenez-Gallego G, J Biol Chem. 2003 Jun 13;278(24):21774-81. Epub 2003 Apr 3. PMID:12676958
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