1hd2
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HUMAN PEROXIREDOXIN 5
OverviewOverview
The peroxiredoxins define an emerging family of peroxidases able to reduce, hydrogen peroxide and alkyl hydroperoxides with the use of reducing, equivalents derived from thiol-containing donor molecules such as, thioredoxin, glutathione, trypanothione and AhpF. Peroxiredoxins have been, identified in prokaryotes as well as in eukaryotes. Peroxiredoxin 5, (PRDX5) is a novel type of mammalian thioredoxin peroxidase widely, expressed in tissues and located cellularly to mitochondria, peroxisomes, and cytosol. Functionally, PRDX5 has been implicated in antioxidant, protective mechanisms as well as in signal transduction in cells. We, report here the 1.5 A resolution crystal structure of human PRDX5 in its, reduced form. The crystal structure reveals that PRDX5 presents a, thioredoxin-like ... [(full description)]
About this StructureAbout this Structure
1HD2 is a [Single protein] structure of sequence from [Homo sapiens] with BR and BEZ as [ligands]. Structure known Active Site: BEZ. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution., Declercq JP, Evrard C, Clippe A, Stricht DV, Bernard A, Knoops B, J Mol Biol. 2001 Aug 24;311(4):751-9. PMID:11518528
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