1gu2
CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C" FROM METHYLOPHILUS METHYLOTROPHUS
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OverviewOverview
The crystal structures of the oxidized and reduced forms of cytochrome c", from Methylophilus methylotrophus were solved from X-ray synchrotron data, to atomic resolution. The overall fold of the molecule in the two redox, states is very similar and is comparable to that of the oxygen-binding, protein from the purple phototrophic bacterium Rhodobacter sphaeroides., However, significant modifications occur near the haem group, in, particular the detachment from axial binding of His95 observed upon, reduction as well as the adoption of different conformations of some, protonatable residues that form a possible proton path from the haem, pocket to the protein surface. These changes are associated with the, previously well characterized redox-Bohr behaviour of this protein., Furthermore they ... [(full description)]
About this StructureAbout this Structure
1GU2 is a [Single protein] structure of sequence from [Methylophilus methylotrophus] with HEC as [ligand]. Structure known Active Site: HEA. Full crystallographic information is available from [OCA].
ReferenceReference
Structural evidence for a proton transfer pathway coupled with haem reduction of cytochrome c" from Methylophilus methylotrophus., Enguita FJ, Pohl E, Turner DL, Santos H, Carrondo MA, J Biol Inorg Chem. 2006 Mar;11(2):189-96. Epub 2005 Dec 10. PMID:16341897
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