Porphobilinogen synthase

Porphobilinogen synthase (PBS) catalyzes the formation of porphobilinogen (PBG) from 2 molecules of aminolevulinic acid (ALA). PBS participates in porphyrin biosynthesis. Levulinic acid (LA) is an inhibitor of PBS. Porphyrin is the precursor of hemes, chlorophyll and vitamin B12. PBS deficiency can be caused by lead and other heavy metal poisoning.

3D structures of porphobilinogen synthase3D structures of porphobilinogen synthase

1aw5 – yPBS (mutant) + Zn – yeast
1qml - yPBS + Hg
1qnv - yPBS + Pb
[[1pv8 – hPBS (mutant) – human
2z0i, 2z1b - PBS - mouse
1w54, 1w56, 1w5m, 1w5n, 1w5o, 1w5p, 1w5q - PaPBS (mutant) + Mg + Zn – Pseudomonas aeruginosa

Porphobilinogen synthase complexPorphobilinogen synthase complex

1b4k - PaPBS + LA + Zn
1b4e - EcPBS + LA + Zn – Escherichia coli
1ylv, 1h7n - yPBS + LA + Zn
1w31 - yPBS + LA derivative + Zn
1h7o - yPBS + ALA + Zn
1h7r, 1h7p, 1eb3, 1gjp - yPBS + inhibitor + Zn
1ohl - yPBS + intermediate + Zn
1i8j, 1l6s, 1l6y - EcPBS + inhibitor + Mg + Zn
2c1h - PBS + inhibitor + Mg – Chlorobium vibrioforme
2c13, 2c14 - PaPBS (mutant) + inhibitor + Mg
2c15, 2c16, 2c18, 2c19 - PaPBS + inhibitor + Mg
1e51 - hPBS + PBG + Zn
1gzg - PaPBS + LA derivative + Mg
2woq - PaPBS + antibiotic + Mg
1w1z - PBS + LA + Mg – Prosthecochloris vibrioformis