Pantothenate kinase

Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX.

3D structures of pantothenate kinase3D structures of pantothenate kinase

1esm – EcPanK + CoA – Escherichia coli
1esn - EcPanK + ANP
1sq5 - EcPanK + ADP + PAU
3tqc - PanK – Coxiella burnetii

PanK I binary complexPanK I binary complex

2ges, 2get, 2zs7, 2geu, 2gev - MtPanK + CoA derivative – Mycobacterium tuberculosis
2zs8, 2zsb - MtPanK + ADP
3af1 - MtPanK + GDP
3af2 - MtPanK + AMPPCP
3af4 - MtPanK + GMPPCP
2zsd - MtPanK + CoA
3avo - MtPanK + PAU
3avp, 3avq - MtPanK + PAU derivative

PanK I ternary complexPanK I ternary complex

2zs9 - MtPanK + ADP + PAU
2zse - MtPanK + AMPPCP + PAU
3af3 - MtPanK + GMPPCP + PAU
2zsf - MtPanK + ADP + ATP
2zsa - MtPanK + ADP + PPT
3aez - MtPanK + GDP + PPT
3af0 - MtPanK + GDP + PAU

PanK IIPanK II

2ews - PanK + ANP – Staphylococcus aureus

PanK IIIPanK III

2gtd - TmPanK – Thermotoga maritima
2f9t – PaPanK – Pseudomonas aeruginosa
2h3g - PanK – Bacillus anthracis
3djc - PanK – Legionella pneumophila

PanK III binary complexPanK III binary complex

2f9w - PaPanK + PAU
3bex - TmPanK + PAU
3bf3 - TmPanK + PPT

PanK III ternary complexPanK III ternary complex

3bf1 - TmPanK + ADP + PAU

Human PanKHuman PanK

2i7n, 3smp - hPanK 1 α + CoA - human
2i7p, 3mk6 - hPanK 3 + CoA
3sms – hPanK 3 + PAU analog