Pantothenate synthetase

Pantothenate synthetase (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate. Pantothenate (vitamin B5) biosynthesis is essential for the virulence of Mycobacterium tuberculosis thus its blockage can be used as a potential drug target.

3D structures of pantothenate synthetase3D structures of pantothenate synthetase

1iho – EcPS – Escherichia coli
1mop, 2a88, 3cov – MtPS (mutant) – Mycobacterium tuberculosis
1ufv - TtPS (mutant) – Thermus thermophilus
1v8f - TtPS
2ejc - PS – Thermotoga maritima
3mue - PS – Salmonella typhimurium
3mxt - CjPS – Campylobacter jejuni
3ag5 - SaPS – Staphylococcus aureus

PS binary complex with adenosine derivativesPS binary complex with adenosine derivatives

1n2g - MtPS + AMPCPP
2a7x - MtPS (mutant) + AMP
3n8h - FtPS + AMP – Francisella tularensis
3q10 - YpPS + AMP – Yersinia pestis
3uk2 - PS + AMP – Burkholderia thailandesis
2a84 - MtPS (mutant) + ATP
2x3f - SaPS + ATP derivative
3inn - PS + ATP – Brucella melitensis
3iob, 3ioc, 3iod, 3ioe - MtPS (mutant) + adenosine derivative

PS binary complex with pantoate derivativesPS binary complex with pantoate derivatives

1n2i - MtPS (mutant) + pantoyl adenylate
1n2j - MtPS (mutant) + pantoate
1n2o - MtPS (mutant) + β-alanine
3q12 - YpPS + pantoate
3ag6 - SaPS + pantoyl adenylate
3guz - EcPS (mutant) + pantoate

PS binary complex with inhibitorPS binary complex with inhibitor

3cow, 3coy, 3coz, 3imc, 3ime, 3img, 3iub, 3iue, 3ivc, 3ivg, 3ivx, 3isj, 3le8 - MtPS (mutant) + inhibitor

PS ternary complexPS ternary complex

2a86 - MtPS (mutant) + β-alanine + AMP
3uy4 - CjPS + pantothenate + AMP
3qtt - FtPS + β-alanine + ATP derivative
1n2b, 1n2e – MtPS + pantoate + AMPCPP

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman