1e7b
CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN COMPLEXED WITH THE GENERAL ANESTHETIC HALOTHANE
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OverviewOverview
Human serum albumin (HSA) is one of the most abundant proteins in the, circulatory system and plays a key role in the transport of fatty acids, metabolites, and drugs. For many drugs, binding to serum albumin is a, critical determinant of their distribution and pharmacokinetics; however, there have as yet been no high resolution crystal structures published of, drug-albumin complexes. Here we describe high resolution crystal, structures of HSA with two of the most widely used general anesthetics, propofol and halothane. In addition, we describe a crystal structure of, HSA complexed with both halothane and the fatty acid, myristate. We show, that the intravenous anesthetic propofol binds at two discrete sites on, HSA in preformed pockets that have been shown to accommodate fatty acids., ... [(full description)]
About this StructureAbout this Structure
1E7B is a [Single protein] structure of sequence from [Homo sapiens] with HLT as [ligand]. Structure known Active Sites: 1, AC1, AC2, AC3, AC4 and AC6. Full crystallographic information is available from [OCA].
ReferenceReference
Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures., Bhattacharya AA, Curry S, Franks NP, J Biol Chem. 2000 Dec 8;275(49):38731-8. PMID:10940303
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