Beta-lactoglobulin

spinqualitylabelsall models Bovine beta-lactoglobulin complex with palmitate 3nq3 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

β-lactoglobulin is a CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.

BLG as studied in the Dubin LabBLG as studied in the Dubin Lab

spinqualitylabelsall models BLG A and BLG B are isoforms that differ by 2 charge units 1beb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

β-lactoglobulin is a dimeric protein that exists in two forms. BLG A and BLG B, which differ by two mutations, one of which is a non-charged residue being replaced by an Aspartic Acid, which at relevant pH values is negatively charged. The result is a protein that exists in two isoforms, which differ by two negative charges (one per monomer).

The differences between these two forms significantly augment the electrostatic potential, making BLG A & BLG B an ideal system for studying the interaction of a protein with a polyelectrolyte.

3D structures of beta-lactoglobulin3D structures of beta-lactoglobulin

1beb, 1bsy, 2blg, 3blg, 1dv9, 1qg5, 1b8e, 2akq, 2q2m, 2q2p, 2q39, 3npo, 3ph5, 3ph6 – bBlac – bovine
1bsq, 1cj5, 1uz2 – bBlac (mutant)
3kza – bBlac/hBlac - horse
1exs – Blac – pig
1yup – Blac – reindeer

Beta-lactoglobulin complexesBeta-lactoglobulin complexes

1b0o, 3uew – bBlac + palmitate
1bso – bBlac + bromododecanoic acid
3nq3, 3nq9, 3qzj, 3qzk, 3uex – bBlac + fatty acid
3ueu - bBlac + lauric acid
3uev - bBlac + myristic acid
1gx9 – bBlac + retinoic acid
1gxa - bBlac + retinoic acid + palmitate
2gj5 – bBlac + vitamin D3
2r56 – bBlac + antibody