1nc3
Crystal structure of E. coli MTA/AdoHcy nucleosidase complexed with formycin A (FMA)Crystal structure of E. coli MTA/AdoHcy nucleosidase complexed with formycin A (FMA)
Template:ABSTRACT PUBMED 12496243
About this StructureAbout this Structure
1nc3 is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Lee JE, Cornell KA, Riscoe MK, Howell PL. Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis. J Biol Chem. 2003 Mar 7;278(10):8761-70. Epub 2002 Dec 20. PMID:12496243 doi:10.1074/jbc.M210836200
- ↑ Lee JE, Settembre EC, Cornell KA, Riscoe MK, Sufrin JR, Ealick SE, Howell PL. Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design. Biochemistry. 2004 May 11;43(18):5159-69. PMID:15122881 doi:http://dx.doi.org/10.1021/bi035492h
- ↑ Lee JE, Smith GD, Horvatin C, Huang DJ, Cornell KA, Riscoe MK, Howell PL. Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis. J Mol Biol. 2005 Sep 23;352(3):559-74. PMID:16109423 doi:http://dx.doi.org/10.1016/j.jmb.2005.07.027