Tripeptidyl peptidase

File:2d5l.png

Crystal Structure of Tripeptidyl peptidase (2d5l)

Tripeptidyl peptidase (TPP) is an enzyme which cleaves N-terminal tripeptides from polypeptides. TPP-I functions in lysosomes, TPP-II is part of the ubiquitin-proteasome pathway. The images at the left and at the right correspond to one representative TPP, i.e. the crystal structure of Pro-Tripeptidyl peptidase-IV from Porphyromonas gingivalis (2d5l).

3D Structures of Tripeptidyl peptidase3D Structures of Tripeptidyl peptidase

TPP-ITPP-I

3ee6 – TPP-I – human
3edy – hTPP-I precursor residues 20-563

TPP-IITPP-II

3lxu – TPP-II residues 463-770 – Drosophila melanogaster

TPP-IVTPP-IV

2eep – PgPro-TPP-IV+inhibitor – Porphyromonas gingivalis
2d5l - PgPro-TPP-IV
2z3w - PgPro-TPP-IV (mutant)
2z3z, 2dcm - PgPro-TPP-IV (mutant)+inhibitor