Signal recognition particle receptor

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Human SRPR α (grey) and β subunit (green) complex with GTP 2fh5

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Signal recognition particle receptor (SRPR) is associated with the endoplasmic reticulum. SRPR is a receptor for the signal recognition particle (SRP). SRPR is a heterodimer with α and β subunits which contain a GTP-binding domain. SRPR α subunit binds to SRP54 subunit of SRP complex. SRPR β subunit is a transmembrane GTPase.

3D structures of SRPR3D structures of SRPR

1nrj – ySRPR α+β subunits + GTP – yeast
2fh5 - hSRPR α+β subunits + GTP – human
2ged - ySRPR β subunit (mutant)
2go5 - hSRPR α subunit + mSRPR β subunit + ribosomal proteins L23, L31, L35 + dSRP19 + dSRP54 + RNA - EM
3dm9, 3dmd, 3e70 – SRPR + GDP – Pyrococcus furiosus

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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