Phosphoglycerate dehydrogenase

Human phosphoglycerate dehydrogenase dimer complex with malate and cofactor NAD 2g76

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Phosphoglycerate dehydrogenase (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate. This is the first step of serine biosynthesis. NAD is used as cofactor. In some cancer cells there is an elevation in PGDH level.

3D structures of phosphoglycerate dehydrogenase3D structures of phosphoglycerate dehydrogenase

1ygy, 3dc2 – MtPGDH – Mycobacterium tuberculosis
3evt - PGDH – Lactobacillus plantarum
3gg9 - PGDH – Ralstonia solanacearum
3k5p - PGDH (mutant) – Brucella melitensis

PGDH binary complex

1sc6, 2p9c, 2p9e, 2p9g - EcPGDH (mutant) + NAD – Escherichia coli
1yba - EcPGDH + NAD
1wwk - PGDH + NAD – Pyrococcus horikoshii
2g76 - PGDH + NAD – human
2ekl - PGDH + NAD – Sulfolobus tokodaii
3ddn - MtPGDH + hydroxypyruvic acid phosphate

PGDH ternary complex

1psd - EcPGDH + serine + NAD
2pa3 - EcPGDH (mutant) + serine + NAD

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Michal Harel, Alexander Berchansky, Joel L. Sussman