RA Mediated T-reg Differentiation

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IntroductionIntroduction

T-regulatory cells (T-regs) are a small subset of CD4+ T-cells that exhibit strong down regulation of immune system activity in their local environment. They are distinguished from other CD4+ T-cells by the expression of FOXP3, a gene regulator.

RARα-RXRα interaction (PDB entry 1dkf)

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Ligand Binding Domain

RARα-RXRα Heterodimer

RARα-RXRα Ligand Interactions

DNA Binding Domain

RXRα-DNA Interactions

DR-5 Specificity

Crystal structure of RXRα-DNA complex PDB entry 1BY4

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Biological SignificanceBiological Significance

ReferencesReferences

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

William Bailey, Michal Harel, Jaime Prilusky, Alexander Berchansky