Major histocompatibility complex

Major Histocompatibility Complex (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response. MHC class I (Major Histocompatibility Complex Class I) are found in all nucleated cells. MHC class II are found in professional antigen-presenting cells like macrophages.

3D structures of MHC3D structures of MHC

Update June 2012

MHC I binary complexMHC I binary complex

1zs8 - mMHC I + β-2-microglobulin – mouse
2hla, 3hla, 1hla - hMHC I + β-2-microglobulin – human
3p73, 3p77 - cMHC I + β-2-microglobulin – chicken

MHC I ternary complexMHC I ternary complex

2yf6, 3bew, 2yez, 2yf1, 2yf5, 3bev – cMHC I α + β-2-microglobulin + peptide
3kpn, 3kpo – hMHC I B + β-2-microglobulin + peptide
3bev, 1kpr, 1k5n, 3nfn, 3mr9, 3mrb, 3mrc, 3mrd, 3mre, 3mrf, 3mrg, 3mrh, 3mri, 3mrj, 3mrk, 3mrl, 3mrm, 3mrn, 3mro, 3mrp, 3mrq, 3mrr, 3ox8, 3oxr, 3oxs, 2xpg, 3pwj, 3pwl, 3pwn, 3pwp, 2x70, 3o3a, 3o3b, 3o3d, 3o3e, 3lv3, 3ln4, 3ln5, 3myj, 3i6l, 3lkn, 3lko, 3lkp, 3lkq, 3lkr, 3lks, 3hpj, 3i6g, 3i6k, 3mgo, 3mgt, 3l3d, 3l3g, 3l3i, 3l3j, 3l3k, 2x4n, 2x4o, 2x4p, 2x4q, 2x4r, 2x4s, 2x4t, 2x4u, 3lka, 3h7b, 3kpl, 3kpm, 3kpn, 3kpo, 3kpp, 3kpq, 3kpr, 3kps, 3giv, 3hcv, 3d18, 3dtx, 3czf, 3fqn, 3fqr, 3fqt, 3fqu, 3fqw, 3fqx, 3d25, 3bvn, 3dx6, 3dx7, 3dx8, 3dxa, 3bo8, 3bp4, 3bp7, 3bgm, 3bh8, 3bh9, 3bhb, 3b3i, 3b6s, 2rfx, 3bze, 3bzf, 3bw9, 3bwa, 3c9n, 2v2w, 2v2x, 2gt9, 2gtw, 2gtz, 2guo, 2nw3, 2fyy, 2fz3, 2hn7, 2cik, 2git, 2hjk, 2hjl, 2h6p, 2d31, 2c7u, 2bck, 2a83, 2axf, 2axg, 2bvo, 2bvp, 2bvq, 1s8d, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1s7q, 1zsd, 2bsr, 2bss, 2bst, 1zhk, 1zhl, 1tvb, 1tvh, 1xr8, 1xr9, 1w0v, 1w0w, 1xh3, 1uxs, 1uxw, 1s9w, 1s9x, 1s9y, 1q94, 1qvo, 1n2r, 1ogt, 1qew, 1jge, 1k5n, 1i7r, 1i7t, 1i7u, 1jf1, 1jht, 1i4f, 1e27, 1e28, 1i1y, 1i1f, 1qqd, 1mhe, 1b0g, 1a9b, 1a9e, 1a1m, 1a1n, 1a1o, 1tmc, 2clr, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hsb, 1hsa - hMHC I α + β-2-microglobulin + peptide
1ktl, 3kww, 3h9h, 3ixa, 3gso, 3gsq, 3gsr, 3gsu, 3gsv, 3gsw, 3gsx, 3ft2, 3ft3, 3ft4, 2av1, 2av7, 1cg9, 1m05, 1m6o, 1kpr, 1ktl - hMHC I α (mutant) + β-2-microglobulin + peptide
1syv, 1n2r, 1syv - hMHC I + β-2-microglobulin + hMHC II peptide
1kjv, 1kjm, 1ed3 – MHC I α + β-2-microglobulin + peptide - rat
2oi9 - mMHC I α + T cell receptor + peptide
1kbg, 3l3h, 3ftg, 3e6f, 3ecb, 3ch1, 3cch, 3cc5, 3cpl, 2zsv, 2zsw, 2zok, 2zol, 3buy, 2ve6, 2e7l, 2fo4, 2cii, 2fwo, 2f74, 1zt1, 1zt7, 1vgk, 1yn6, 1yn7, 1zhb, 1wbx, 1wby, 1wbz, 1rjy, 1rjz, 1rk0, 1rk1, 1t0m, 1t0n, 1s7q, 1s7r, 1s7s, 1s7t, 1s7u, 1s7v, 1s7w, 1s7x, 1lk2, 1kpu, 1kpv, 1n3n, 1nan, 1n59, 1n5a, 1ffn, 1ffo, 1ffp, 1g7p, 1g7q, 1lek, 1leg, 1inq, 1juf, 1k8d, 1jpf, 1jpg, 1fg2, 1qlf, 1bz9, 1kbg, 1hoc, 2mha, 1vad, 1vac, 3roo, 3quk, 3qul, 3rol - mMHC I + β-2-microglobulin + peptide
2qri - mMHC I/β-2-microglobulin/peptide
2qrs, 2qrt - mMHC I (mutant)/β-2-microglobulin/peptide
1mhc, 2clv, 2clz, 1fzj, 1fzk, 1fzm, 1fzo, 1ddh - mMHC I (mutant) + β-2-microglobulin + peptide
3e2h, 3e3q, 2e7l - mMHC I α (mutant) + T cell receptor + peptide
1nez - mMHC I + β-2-microglobulin + CD8 α chain
3rwc, 3rwd, 3rwe, 3rwf, 3rwg, 3rwh, 3rwi, 3rwj - MHC I + β-2-microglobulin + peptide – Rhesus macaque
3qq3, 3qq4 - MHC I + β-2-microglobulin + peptide - pig

MHC I quaternary complexMHC I quaternary complex

3qdg, 3qdj, 3qdm, 3qeq, 3mv7, 3mv9, 3h9s, 3gsn, 3d39, 3d3v, 3ffc, 2vlj, 2vlk, 2vll, 2vlr, 2j8u, 2p5e, 2p5w, 2pye, 2gj6, 2f54, 2esv, 2bnq, 2bnr, 1lp9, 1oga, 1mi5, 1qrn - hMHC I α + T cell receptor + β-2-microglobulin + peptide
3kxf, 3mv8, 2jcc, 2uwe - hMHC I α (mutant) + T cell receptor + β-2-microglobulin + peptide
2f53 - hMHC I α + T cell receptor + β-2-microglobulin (mutant) + peptide
1p7q, 1im9 - hMHC I α + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide
2dyp - hMHC I α (mutant) + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide
3qzw, 3dmm, 1bqh, 1akj - hMHC I α + β-2-microglobulin + CD8 α + peptide
1im3 - hMHC I α + β-2-microglobulin + cytomegalovirus protein US2 + peptide
3cii, 3cdg - hMHC I α + β-2-microglobulin + CD94 ectodomain + NKG2A/NKG2B integral membrane protein + peptide
3hae, 3gjf, 3cvh, 1w72 - hMHC I α + β-2-microglobulin + antibody + peptide
1g6r, 2ckb, 3pqy, 2z31, 1nam, 1mwa, 1g6r, 2ckb - mMHC I + T cell receptor + β-2-microglobulin + peptide
2oi9 - mMHC I (mutant) + T cell receptor + β-2-microglobulin + peptide
1p1z, 1p4l, 1qo3 - mMHC I + β-2-microglobulin + natural killer cell receptor LY49C + peptide
3c8k - mMHC I (mutant) + β-2-microglobulin + natural killer cell receptor LY49C + peptide

MHC IIMHC II

3lqz, 2bc4, 1hdm - hMHC II α+β
3pdo, 3pgc, 3pgd, 1a6a - hMHC II α+β+γ
3cup, 2p24, 1lnu, 1fng - mMHC II α+β
1fne - mMHC II α+β (mutant)
3lqz - hMHC II α+β DP2

MHC II binary complexMHC II binary complex

1h15 - hMHC II α+β + DNA polymerase peptide
1fv1 - hMHC II α+β + myelin basic protein
3o6f, 2wbj - hMHC II α+β + T cell receptor
3l6f, 3c5j, 2q6w, 2fse, 1t5w, 1s9v, 1uvq, 1h15, 1fv1 – hMHC II α+β + peptide
1dlh - hMHC II α+β + enterotoxin
3c5z, 3c60, 3c6l - mMHC II α+β + T cell receptor
1r5v, 1k2d, 1muj, 1kt2, 1ktd, 1f3j, 1es0, 1iak, 1iea, 1ieb, 1f3j - mMHC II α+β + peptide
1aqd - mMHC II α+β + MHC I peptide
1r5w, 1i3r - mMHC II α+β (mutant) + peptide

MHC II ternary complexMHC II ternary complex

1zgl, 1j8h, 1fyt - hMHC II α+β + T cell receptor + peptide
2iam, 2ian, 1ymm – hMHC II α+β + T cell receptor (mutant) + peptide
2ipk, 2g9h, 1pyw, 1jwm, 1jws, 1jwu, 1klg, 1klu, 1hxy, 1d5m, 1d5x, 1d5z, 1d6e, 2seb, 1seb - hMHC II α+β + enterotoxin + peptide
1sje, 1sjh, 1t5x, 1lo5 - hMHC II α+β + enterotoxin (mutant) + peptide
1r5i - hMHC II α+β + mycoplasma arthritidis mitogen+ peptide
2oje - mMHC II α+β + mycoplasma arthritidis mitogen+ peptide
2xn9, 3qib, 1zgl, 3qiu, 3qiw, 3mbe - mMHC I + T cell receptor + peptide
2pxy, 1u3h - mMHC II α+β + T cell receptor (mutant) + peptide
1jl4 - mMHC II α+β + CD4 + peptide

MHC II quaternary complexMHC II quaternary complex

2icw - mMHC II α+β + T cell receptor + mycoplasma arthritidis mitogen+ peptide