3kec
Crystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compoundCrystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compound
Template:ABSTRACT PUBMED 20005097
About this StructureAbout this Structure
3kec is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Schnute ME, O'Brien PM, Nahra J, Morris M, Howard Roark W, Hanau CE, Ruminski PG, Scholten JA, Fletcher TR, Hamper BC, Carroll JN, Patt WC, Shieh HS, Collins B, Pavlovsky AG, Palmquist KE, Aston KW, Hitchcock J, Rogers MD, McDonald J, Johnson AR, Munie GE, Wittwer AJ, Man CF, Settle SL, Nemirovskiy O, Vickery LE, Agawal A, Dyer RD, Sunyer T. Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorg Med Chem Lett. 2010 Jan 15;20(2):576-80. Epub 2009 Nov 22. PMID:20005097 doi:10.1016/j.bmcl.2009.11.081
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OCACategories:
- Pages with broken file links
- Homo sapiens
- Collins, B.
- Pavlovsky, A G.
- Schnute, M E.
- Shieh, H S.
- Collagen degradation
- Disease mutation
- Disulfide bond
- Extracellular matrix
- Glycoprotein
- Hydrolase
- Hydrolase-hydrolase inhibitor complex
- Metal-binding
- Metalloprotease
- No contact to zn
- Protease
- S1' inhibitor
- S1' specificity pocket
- Secreted
- Selective mmp-13 inhibitor
- Zymogen