3fit
FHIT (FRAGILE HISTIDINE TRIAD PROTEIN) IN COMPLEX WITH ADENOSINE/SULFATE AMP ANALOG
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OverviewOverview
BACKGROUND: The fragile histidine triad (FHIT) protein is a member of the, large and ubiquitous histidine triad (HIT) family of proteins. It is, expressed from a gene located at a fragile site on human chromosome 3, which is commonly disrupted in association with certain cancers. On the, basis of the genetic evidence, it has been postulated that the FHIT, protein may function as a tumor suppressor, implying a role for the FHIT, protein in carcinogenesis. The FHIT protein has dinucleoside polyphosphate, hydrolase activity in vitro, thus suggesting that its role in vivo may, involve the hydrolysis of a phosphoanhydride bond. The structural analysis, of FHIT will identify critical residues involved in substrate binding and, catalysis, and will provide insights into the in vivo function of ... [(full description)]
About this StructureAbout this Structure
3FIT is a [Single protein] structure of sequence from [Homo sapiens] with FRU, SO4 and A as [ligands]. Structure known Active Site: AVE. Full crystallographic information is available from [OCA].
ReferenceReference
MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family., Lima CD, D'Amico KL, Naday I, Rosenbaum G, Westbrook EM, Hendrickson WA, Structure. 1997 Jun 15;5(6):763-74. PMID:9261067
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