2nnx
Crystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide DismutaseCrystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide Dismutase
Template:ABSTRACT PUBMED 17092942
About this StructureAbout this Structure
2nnx is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
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ReferenceReference
- ↑ Wang J, Caruano-Yzermans A, Rodriguez A, Scheurmann JP, Slunt HH, Cao X, Gitlin J, Hart PJ, Borchelt DR. Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability. J Biol Chem. 2007 Jan 5;282(1):345-52. Epub 2006 Nov 8. PMID:17092942 doi:10.1074/jbc.M604503200
- ↑ Winkler DD, Schuermann JP, Cao X, Holloway SP, Borchelt DR, Carroll MC, Proescher JB, Culotta VC, Hart PJ. Structural and biophysical properties of the pathogenic SOD1 variant H46R/H48Q. Biochemistry. 2009 Apr 21;48(15):3436-47. PMID:19227972 doi:10.1021/bi8021735