Sandbox 50

Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. spinqualitylabelsall models Adenylate_Kinase Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image DescriptionDescription Adenylate Kinase, also known as ADK, is an enzyme that catalyzes the reversible transfer of phosphate between ATP and AMP. It plays an important role in cell maintenance and cell growth being involved with energy metabolism, signaling, and nucleotide synthesis. The enzyme is found in many different organisms, and the following images shows the structure of Adenylate kinase from Yersinia pestis, also known as yeast. StructureStructure Adenylate kinase is made up of 214 amino acids, and the of the protein can be seen on the right in light blue surrounding the non-hydrolysable substrate analogue (red). The of the protein contains 12 alpha helices (yellow) and 7 beta sheets (green). This secondary structure is held together by , which are anti-parallel between the beta sheets. ResiduesResidues The amino acid of ADK, seen in gray, is buried in the interior of the protein. While the , all the charged and polar side chains (purple), are either on the surface of the protein or exposed in the active site.