Human topoisomerase IIbeta in complex with DNA and etoposideHuman topoisomerase IIbeta in complex with DNA and etoposide
Crystal structure of a large fragment of human type II topoisomerases (TOP2) complexed to DNA and to the anticancer drug etoposide to reveal structural details of drug-induced stabilization of a cleavage complex[1]. The interplay at the between the , the , and the drug explains the structure-activity relations of etoposide derivatives and the molecular basis of drug-resistant mutations. Also, we can see how the , the , and the interact.
ReferencesReferences
- ↑ Wu CC, Li TK, Farh L, Lin LY, Lin TS, Yu YJ, Yen TJ, Chiang CW, Chan NL. Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide. Science. 2011 Jul 22;333(6041):459-62. PMID:21778401 doi:10.1126/science.1204117