Argonaute

The Argonaute family of proteins is central to the RNA-induced silencing in eukaryotic organisms ^[1]. It was first found to be important for plant development and for germline stem-cell division in Drosophila Melanogaster, but further research revealed a much broader and essential role in protein synthesis, maintenance of genome integrity and RNA stability ^[2].

Structure of human Argonaute2 protein in complex with target RNA (PDB Entry 4EI1)

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The Argonaute FamilyThe Argonaute Family

Role in RNA interferenceRole in RNA interference

MembersMembers

StructureStructure

N DomainN Domain

Paz DomainPaz Domain

Mid DomainMid Domain

Piwi DomainPiwi Domain

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

João Rodrigues, Michal Harel, Joel L. Sussman, Alexander Berchansky

[1]

[2]