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Outer surface protein C (OspC) of Borrelia burgdorferiOuter surface protein C (OspC) of Borrelia burgdorferi

Outer surface protein C (OspC) is one of the major antigens on the surface of the Lyme disease spirochete, Borrelia burgdorferi. It greatly differs from other outer surface proteins, such as OspA and OspB in both structure and function. The uniqueness of OspC is that it comes into play when the pathogen is being transmitted to humans or other mammals. OspC is being produced by Borrelia burgdorferi when infected ticks feed, but its synthesis is known to slow down greatly after transmission to a mammalian host. It was demonstrated that those spirochetes that lack OspC are capable to replicate inside and migrate to the salivary glands of the tick vector but do not infect mammals ^[1]

</ref>. Therefore, OspC is believed to determine virulence of the spirochete to mammals, including humans.

Basic StructureBasic Structure

Main FunctionMain Function

Putative Binding SitePutative Binding Site

Role of OspC in Lyme DiseaseRole of OspC in Lyme Disease

OspC-based Vaccine Against Lyme DiseaseOspC-based Vaccine Against Lyme Disease

Main Advantages of Developing OspC-based VaccineMain Advantages of Developing OspC-based Vaccine

Main Problems with Application of OspC-based VaccineMain Problems with Application of OspC-based Vaccine

↑ D. Kumaran1, S. Eswaramoorthy1, B.J. Luft2, S. Koide3, J.J. Dunn1, C.L. Lawson1,4 and S. Swaminathan1. Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.The EMBO Journal (2001) 20, 971 - 978 [1]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Ekaterina Shnaydman, Paramjit Singh, Olivia Cary, Michal Harel, Alexander Berchansky

[1] D. Kumaran1, S. Eswaramoorthy1, B.J. Luft2, S. Koide3, J.J. Dunn1, C.L. Lawson1,4 and S. Swaminathan1. Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.The EMBO Journal (2001) 20, 971 - 978 [1]

[1]

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Contents

Outer surface protein C (OspC) of Borrelia burgdorferiOuter surface protein C (OspC) of Borrelia burgdorferi

Basic StructureBasic Structure

Main FunctionMain Function

Putative Binding SitePutative Binding Site

Role of OspC in Lyme DiseaseRole of OspC in Lyme Disease

OspC-based Vaccine Against Lyme DiseaseOspC-based Vaccine Against Lyme Disease

Main Advantages of Developing OspC-based VaccineMain Advantages of Developing OspC-based Vaccine

Main Problems with Application of OspC-based VaccineMain Problems with Application of OspC-based Vaccine

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Outer surface protein C (OspC) of Borrelia burgdorferiOuter surface protein C (OspC) of Borrelia burgdorferi

Basic StructureBasic Structure

Main FunctionMain Function

Putative Binding SitePutative Binding Site

Role of OspC in Lyme DiseaseRole of OspC in Lyme Disease

OspC-based Vaccine Against Lyme DiseaseOspC-based Vaccine Against Lyme Disease

Main Advantages of Developing OspC-based VaccineMain Advantages of Developing OspC-based Vaccine

Main Problems with Application of OspC-based VaccineMain Problems with Application of OspC-based Vaccine

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