3br9
Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone InhibitorCrystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor
Template:ABSTRACT PUBMED 18242088
About this StructureAbout this Structure
3br9 is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Zhou Y, Webber SE, Murphy DE, Li LS, Dragovich PS, Tran CV, Sun Z, Ruebsam F, Shah AM, Tsan M, Showalter RE, Patel R, Li B, Zhao Q, Han Q, Hermann T, Kissinger CR, Lebrun L, Sergeeva MV, Kirkovsky L. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5- hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1413-8. Epub 2008 Jan 8. PMID:18242088 doi:S0960-894X(08)00010-3
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OCACategories:
- Pages with broken file links
- Hepatitis c virus
- RNA-directed RNA polymerase
- Han, Q.
- Kissinger, C R.
- Showalter, R E.
- Zhao, Q.
- Antiviral
- Host-virus interaction
- Hydrolase
- Metal-binding
- Nucleotide-binding
- Nucleotidyltransferase
- Protein-ligand complex
- Ribonucleoprotein
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Transcription
- Transcription regulation
- Transferase
- Viral nucleoprotein