2fkl

Gene:

Related:

Structural annotation:
Resources:	InterPro : Ipr008154, Ipr013803, Ipr015849, Ipr011178, Ipr002223, Ipr008155 Pfam : PF02177 UniProt : P05067

Functional annotation:
Cellular component:	coated pit extracellular region integral to plasma membrane integral to membrane membrane cell surface
Biological process:	cell adhesion neuromuscular process apoptosis cellular copper ion homeostasis endocytosis Notch signaling pathway
Molecular function:	endopeptidase inhibitor activity identical protein binding binding protein binding serine-type endopeptidase inhibitor activity zinc ion binding heparin binding metal ion binding iron ion binding copper ion binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

About this StructureAbout this Structure

2fkl is a 2 chain structure of Amyloid precursor protein with sequence from Homo sapiens. Full crystallographic information is available from OCA.

↑ Kong GK, Adams JJ, Harris HH, Boas JF, Curtain CC, Galatis D, Masters CL, Barnham KJ, McKinstry WJ, Cappai R, Parker MW. Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. J Mol Biol. 2007 Mar 16;367(1):148-61. Epub 2006 Dec 21. PMID:17239395 doi:10.1016/j.jmb.2006.12.041