1eo1
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Solution structure of hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum
OverviewOverview
The solution structure of MTH1175, a 124-residue protein from the archaeon Methanobacterium thermoautotrophicum has been determined by NMR spectroscopy. MTH1175 is part of a family of conserved hypothetical proteins (COG1433) with unknown functions which contains multiple paralogs from all complete archaeal genomes and the archaeal gene-rich bacterium Thermotoga maritima. Sequence similarity indicates this protein family may be related to the nitrogen fixation proteins NifB and NifX. MTH1175 adopts an alpha/beta topology with a single mixed beta-sheet, and contains two flexible loops and an unstructured C-terminal tail. The fold resembles that of Ribonuclease H and similar proteins, but differs from these in several respects, and is not likely to have a nuclease activity.
About this StructureAbout this Structure
1EO1 is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.
ReferenceReference
NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum., Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA, J Struct Funct Genomics. 2000;1(1):15-25. PMID:12836677
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OCA- Pages with broken file links
- Methanothermobacter thermautotrophicus
- Single protein
- Arrowsmith, C H.
- Cort, J R.
- Kennedy, M A.
- NESG, Northeast Structural Genomics Consortium.
- Mixed a/b protein
- Mixed beta sheet
- Nesg
- Northeast structural genomics consortium
- Protein structure initiative
- Psi
- Strand order 321456
- Strands 2 and 6 antiparallel to rest.
- Structural genomics