3gnv
HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1bHCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1b
Template:ABSTRACT PUBMED 19507864
About this StructureAbout this Structure
3gnv is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus isolate. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Vandyck K, Cummings MD, Nyanguile O, Boutton CW, Vendeville S, McGowan D, Devogelaere B, Amssoms K, Last S, Rombauts K, Tahri A, Lory P, Hu L, Beauchamp DA, Simmen K, Raboisson P. Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase. J Med Chem. 2009 Jul 23;52(14):4099-102. PMID:19507864 doi:10.1021/jm9005548
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OCACategories:
- Pages with broken file links
- Hepatitis c virus isolate
- RNA-directed RNA polymerase
- Bondt, H De.
- Nyanguile, O.
- 1 5-benzodiazepine
- Apoptosis
- Atp-binding
- Capsid protein
- Cell membrane
- Endoplasmic reticulum
- Envelope protein
- Fusion protein
- Glycoprotein
- Helicase
- Hepatitis c virus
- Host-virus interaction
- Hydrolase
- Interferon antiviral system evasion
- Lipid droplet
- Lipoprotein
- Membrane
- Metal-binding
- Mitochondrion
- Multifunctional enzyme
- Ns5b
- Nucleotide-binding
- Nucleotidyltransferase
- Nucleus
- Oncogene
- Palmitate
- Phosphoprotein
- Polymerase
- Protease
- Ribonucleoprotein
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Secreted
- Serine protease
- Sh3-binding
- Sulfone
- Thiol protease
- Transcription
- Transcription regulation
- Transferase
- Transmembrane
- Viral nucleoprotein
- Virion