2v22
REPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORSREPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORS
Template:ABSTRACT PUBMED 17051658
About this StructureAbout this Structure
2v22 is a 4 chain structure of Cell Division Protein Kinase 2 and Cyclin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Andrews MJ, Kontopidis G, McInnes C, Plater A, Innes L, Cowan A, Jewsbury P, Fischer PM. REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors. Chembiochem. 2006 Dec;7(12):1909-15. PMID:17051658 doi:10.1002/cbic.200600189
- ↑ Kontopidis G, McInnes C, Pandalaneni SR, McNae I, Gibson D, Mezna M, Thomas M, Wood G, Wang S, Walkinshaw MD, Fischer PM. Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design. Chem Biol. 2006 Feb;13(2):201-11. PMID:16492568 doi:http://dx.doi.org/10.1016/j.chembiol.2005.11.011
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OCACategories:
- Pages with broken file links
- Homo sapiens
- Non-specific serine/threonine protein kinase
- Andrews, M J.
- Cowan, A.
- Fischer, P M.
- Innes, L.
- Jewsbury, P.
- Kontopidis, G.
- Mcinnes, C.
- Plater, A.
- Active
- Atp-binding
- Cdk2
- Cell cycle
- Cell division
- Cyclin
- Cyclin groove
- Inhibition
- Kinase
- Mitosis
- Nonpeptide
- Nucleotide-binding
- Phosphorylation
- Serine/threonine-protein kinase
- Transferase