3l5e
Structure of BACE Bound to SCH736062Structure of BACE Bound to SCH736062
Template:ABSTRACT PUBMED 20043696
About this StructureAbout this Structure
3l5e is a 2 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Zhu Z, Sun ZY, Ye Y, Voigt J, Strickland C, Smith EM, Cumming J, Wang L, Wong J, Wang YS, Wyss DF, Chen X, Kuvelkar R, Kennedy ME, Favreau L, Parker E, McKittrick BA, Stamford A, Czarniecki M, Greenlee W, Hunter JC. Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation ( parallel) (1). J Med Chem. 2010 Feb 11;53(3):951-65. PMID:20043696 doi:10.1021/jm901408p