1ial
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IMPORTIN ALPHA, MOUSE
OverviewOverview
Importin alpha is the nuclear import receptor that recognizes classical, monopartite and bipartite nuclear localization signals (NLSs). The, structure of mouse importin alpha has been determined at 2.5 A resolution., The structure shows a large C-terminal domain containing armadillo, repeats, and a less structured N-terminal importin beta-binding domain, containing an internal NLS bound to the NLS-binding site. The structure, explains the regulatory switch between the cytoplasmic, high-affinity, form, and the nuclear, low-affinity form for NLS binding of the nuclear, import receptor predicted by the current models of nuclear import., Importin beta conceivably converts the low- to high-affinity form by, binding to a site overlapping the autoinhibitory sequence. The structure, also has ... [(full description)]
About this StructureAbout this Structure
1IAL is a [Single protein] structure of sequence from [Mus musculus]. Structure known Active Site: AIS. Full crystallographic information is available from [OCA].
ReferenceReference
Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha., Kobe B, Nat Struct Biol. 1999 Apr;6(4):388-97. PMID:10201409
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