Eric Martz's Favorites

Eric Martz's FavoritesEric Martz's Favorites

• 2006 - Tamiflu bound to avian influenza neuraminidase N1, 2hu4 has tamiflu bound, while 2hty lacks this ligand. Tamiflu was designed for N2/N9, not N1. Its antiviral activity via N1 is fortunate but surprising. Comparison of these two structures shows that tamiflu pulls N1 loop 147-152 into close contact, a case of "induced fit". Another surprise was a cavity near tamiflu that could serve as a target for designing better anti-avian influenza drugs.
  • More background.
  • Lesson plan on this topic.
  • Morphs of the induced fit.
  • Cavity near tamiflu is shown nicely in View 2 of this chapter in a tutorial about developing tutorials using Jmol.

To be added: MHC class I; domain-switched antibody; flagellar hook; dna-binding morph.