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6-phosphogluconate dehydrogenase

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6-phosphogluconate dehydrogenase (6PDH) catalyzes the decarboxylation reduction of 6-phosphogluconate (6PG) to ribulose 5-phosphate and CO2. This reaction is part of the pentose phosphate pathway. NADP is a cofactor in this reaction and is converted to NADPH.

3D structures of 6-phosphogluconate dehydrogenase3D structures of 6-phosphogluconate dehydrogenase

2pgd - s6PDH – sheep
1pgj - 6PDH – Trypanosoma brucei
2p4q - 6PDH – yeast
2zyg - 6PDH (mutant) – Klebsiella pneumonia
4e21 - 6PDH – Geobacter metallireducens

6PDH binary complex

1pgn – s6PDH + Br-NADP
1pgo - s6PDH + NADP
1pgp - s6PDH + 6PG
1pgq - s6PDH + AMP
2jkv - 6PDH + NADP – human
2zya - Ec6PDH (mutant) + 6PG – Escherichia coli
2w8z, 2w90 - 6PDH + 6PG – Geobacillus stearothermophilus
2iyo - Ll6PDH + 6PG – Lactococcus lactis
2zyd - Ec6PDH (mutant) + glucose

6PDH ternary complex

2iz1 - Ll6PDH + inhibitor + ADP
3fwn - Ec6PDH (mutant) + ADP + 6PG

6PDH quaternary complex

2iyp - Ll6PDH + ADP + ribulose 5-phosphate + NADP
2iz0 - Ll6PDH + inhibitor + ADP + NADP

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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